Migrenium® Neo

Ibuprofen It belongs to nonsteroidal anti-inflammatory drugs (NSAIDs).
Ibuprofen reduces the severity of pain, swelling and fever during inflammation.
Caffeine It is a stimulant and provides a faster onset and longer duration of analgesic effect, thereby increasing the effectiveness of ibuprofen.
The drug Migrenium® Neo has a rapid targeted effect against pain (analgesic), antipyretic and anti-inflammatory effects. When using a combination of ibuprofen and caffeine, pain reduction is 30% more pronounced and occurs 30% faster compared to ibuprofen.

The drug Migrenium® Neo is used in adults over the age of 18 for the short-term treatment of moderate pain, such as toothache, menstrual pain (algodismenorrhea), headache, migraine.

Overdose symptoms
Ibuprofen
In children, overdose symptoms may occur after taking a dose exceeding 400 mg/kg. In adults, the dose-dependent effect of overdose may be less pronounced.
Overdose symptoms may include nausea, abdominal pain, vomiting, or less commonly diarrhea. Eye trembling, blurred vision, tinnitus, headache, or gastrointestinal bleeding may also occur. With more serious poisoning, there are manifestations from the central nervous system in the form of dizziness, drowsiness, sometimes agitation, trembling, disorientation, loss of consciousness or coma. Seizures are possible.
Caffeine
Symptoms of toxicity may develop when taking high doses of caffeine (250-500 mg or more) if they enter the body within a short period of time. The early symptoms of acute caffeine poisoning are trembling and anxiety. Then nausea, vomiting, rapid heartbeat (tachycardia) and impaired consciousness develop.

Like all medications, Migrenium® is used Neo can cause undesirable reactions, but they do not occur in everyone.
Stop taking Migrenium®. Seek immediate medical attention if any of the following signs of adverse reactions occur:
• severe skin reactions with high body temperature, pain and swelling in the throat, severe itching, peeling of the skin, formation of blisters (blisters) on the skin and mucous membranes of the lips, eyes, mouth, nose, genitals, accompanied by bleeding (anaphylactic reactions, exfoliative and bullous dermatoses, toxic epidermal necrolysis, Lyell's syndrome, Stevens-Johnson syndrome, erythema multiforme);
• white or red, swollen, itchy skin rashes (urticaria);
• rapid swelling of the skin (lips, eyelids), subcutaneous tissue, mucous or submucosal membranes (tongue, tonsils, soft palate) (Quincke's edema);
• itchy skin rashes, skin swelling and/or breathing difficulties (cough, shortness of breath, dyspnea, wheezing, chest tightness, blue skin, hoarseness of voice, decreased blood pressure (allergic reactions and anaphylactic reactions, respiratory tract reactions));
• through-the-wall defect of the stomach and/or duodenum (perforation), vomiting with blood, black stools (chalk), bloody vomiting (gastrointestinal bleeding);
• severe headache, high body temperature, neck stiffness or intolerance to bright light (aseptic meningitis);
• decreased or absent urine, anorexia, nausea, vomiting, bloating, diarrhea or constipation, weakness, sweating, lethargy (acute renal failure);
• shortness of breath, rapid heartbeat, fatigue, swelling, mainly in the lower extremities (heart failure), the formation of clots leading to blockage of blood vessels (thrombotic complications). (For more information about all possible adverse reactions, see the leaflet)

Do not take Migrenium® Neo if:
• You are allergic to ibuprofen, caffeine, or any other components of the drug (listed in section 6 of the leaflet);
• Have you ever had the following allergic reactions after taking acetylsalicylic acid or other NSAIDs: bronchospasm, bronchial asthma, runny nose (rhinitis), angioedema or urticaria;
• you have hematopoiesis disorders, the cause of which is unknown;
• you have erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer of the stomach and duodenum, chronic inflammatory disease of the gastrointestinal tract, characterized by damage to the intestinal wall with the development of complications (Crohn's disease), inflammatory disease of the colon, accompanied by the formation of ulcers on the mucous membrane (ulcerative colitis)), existing or recurrent peptic ulcer, current or previous bleeding (two or more separate episodes of confirmed ulcer or bleeding);
• You have had gastrointestinal bleeding or violations of the integrity of the gastrointestinal wall (gastrointestinal perforation) associated with previous NSAID therapy;
• You have been diagnosed with a brain hemorrhage or other active bleeding;
• You have severe liver or kidney failure;
• You have severe heart failure;
• you have a condition in which the heart does not provide organs and tissues with an adequate amount of blood, despite the use of compensation mechanisms (decompensated heart failure), or there is a period after surgery aimed at reducing the symptoms of coronary heart disease (coronary artery bypass grafting);
• You have a hereditary disease associated with impaired blood clotting (hemophilia) and other blood clotting disorders, an increased tendency to bleeding (hemorrhagic diathesis);
• You have anxiety disorders (fear of open spaces, crowded places (agoraphobia), panic attacks);
• You have organic diseases of the cardiovascular system (acute myocardial infarction, atherosclerosis);
• You have cardiac arrhythmias (episodes of palpitations (paroxysmal tachycardia), abnormal heart contractions (ventricular extrasystole));
• You have high blood pressure (hypertension);
• You have a sleep disorder;
• You are pregnant (more than 20 weeks old).

Tell your doctor that you are taking, have recently taken, or may start taking any other medications.
The full list of medications can be found in the leaflet.

The holder of the registration certificate
JSC Biochemist, Russian Federation
15A Vasenko St., Saransk, 430030, Republic of Mordovia
Manufacturer
JSC Biochemist, Russian Federation
Address: 15A Vasenko St., Saransk, 430030, Republic of Mordovia
Phone: +7 (8342) 38 03 68
Email: biohimic@promomed.pro
Internet address: promomed.pro
The organization that accepts consumer claims
JSC Biochemist, Russian Federation
Address: 15A Vasenko St., Saransk, 430030, Republic of Mordovia
Phone number: 8 800 222 95 63; 8 800 777 86 04 ( around the clock)
Email: hot_line@promomed.pro

Keep the drug out of the reach of the child so that the child cannot see it. Do not take the drug after the expiration date (shelf life) indicated on the pack after "Good before". The expiration date is the last day of the given month. Do not store at temperatures above 25 °C. Store in the original packaging (pack) to protect from light.

As with other NSAIDs, while taking Migrenium® It is also possible to develop undesirable reactions, such as dizziness, drowsiness, lethargy, or visual disturbances. If you experience the above adverse reactions, it is recommended to refrain from driving vehicles and working with mechanisms.

If you are pregnant or breastfeeding, think you are pregnant, or plan to become pregnant, consult your doctor or pharmacy employee before taking the drug.