Josamycin is active against Gram-positive bacteria and Gram-negative bacteria. The drug disrupts protein synthesis in the microbial cell, thereby slowing down the growth and reproduction of microorganisms sensitive to it. Josamycin has a drug effect at a fairly high rate 1 hour after ingestion of the drug.

If there is no improvement or you feel worse, you should consult a doctor.

The drug VILPRAMYCIN SAR® is used in adults and children aged from 1 year with a body weight of at least 10 kg for the treatment of infectious and inflammatory diseases,
caused by microorganisms sensitive to the drug:

• upper respiratory tract and ENT infections: tonsillitis, pharyngitis, paratonsillitis, laryngitis, otitis media, sinusitis, diphtheria (in addition to treatment with diphtheria toxoid), scarlet fever (in case of hypersensitivity to penicillin);
• lower respiratory tract infections: acute bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia, including those caused by atypical pathogens, whooping cough, psittacosis;
• infections in dentistry: gingivitis, pericoronitis, periodontitis, alveolitis, alveolar abscess;
• infections in ophthalmology: blepharitis, dacryocystitis;
• infections of the skin and soft tissues: folliculitis, furuncle, furunculosis, abscess, anthrax, erysipelas, acne, lymphangitis, lymphadenitis, phlegmon, panaritium, wound (including postoperative) and burn infections;
• infections of the genitourinary system: urethritis, cervicitis, epididymitis, prostatitis caused by chlamydia and/or mycoplasma, gonorrhea, syphilis (with hypersensitivity to penicillin), venereal lymphogranuloma;
diseases of the gastrointestinal tract associated with Helicobacter pylori: peptic ulcer of the stomach and duodenum, chronic gastritis and others.

To date, there is no data on the specific symptoms of overdose. In case of overdose, the symptoms described in the "Adverse reactions" section of the instructions should be expected, especially from the gastrointestinal tract.

Some adverse reactions can be serious and life-threatening. Tell your doctor immediately if you experience any of the following adverse reactions while taking VILPRAMYCIN SAR®:

• vomiting, may occur infrequently;
• diarrhea, may occur infrequently;
• rapidly developing and increasing swelling of the skin, mucous membranes – occurs abruptly, develops spontaneously and resolves just as quickly (angioedema), may occur rarely;
• fever, pain, redness and swelling of the oral mucosa, ulceration (stomatitis), may occur rarely;
• fainting or loss of consciousness, impaired breathing, decreased blood pressure, pale or bluish, cold, moist skin (anaphylactic reactions), may occur rarely;
• fever and "malaise", followed by a widespread rash on the skin and mucous membranes in the form of spots, blisters, weeping erosions, crusts (Stevens-Johnson syndrome), may occur very rarely;
skin rash or skin lesions with a pinkish red ring and pale center that may be itchy, scaly, or filled with fluid. The rash may appear more often on the palms or soles of the feet (erythema multiforme), may occur very rarely;
• cramping abdominal pain due to deterioration of the general condition of the body, frequent stools (pseudomembranous colitis), may occur very rarely;
fever and "malaise", followed by a widespread rash on the skin and mucous membranes in the form of spots, blisters, weeping erosions, crusts, skin detachment (toxic epidermal necrolysis), the frequency is unknown.

Do not take VILPRAMYCIN SAR®.:

• if you or your child are allergic to josamycin or other macrolide antibiotics, or any other components of the drug (listed in section 6 of the leaflet);
• if you or your child have severe liver dysfunction.

Tell your doctor that you are using, have recently used, or may start using any other medications.
Your doctor needs to know about the medications you are using to take into account possible adverse reactions that may develop due to the interaction of various medications with VILPRAMYCIN SAR®, and possibly adjust the doses of the medications you use.

(For more information, see the instructions in the leaflet)

Registration certificate holder
JSC Biochemist, Russian Federation
15A Vasenko St., Saransk, Republic of Mordovia, 430030
Manufacturer
JSC Biochemist, Russian Federation
Address: 15A Vasenko str., Saransk, 430030, Republic of Mordovia
Phone number: +7 (8342) 38 03 68
Email: biohimic@promomed.pro
Internet address: promomed.ru
Organization that accepts consumer claims
JSC Biochemist, Russian Federation
Address: 15A Vasenko str., Saransk, 430030, Republic of Mordovia
Phone number: 8 800 222 95 63; 8 800 777 86 04 ( around the clock)
Email: hot_line@promomed.pro

Store at a temperature not exceeding 25 ° C. Store in the original packaging (pack) to protect from light.

There was no effect of josamycin on the ability to drive vehicles and work with mechanisms.