Meldonium (trimethylhydrazinium propionate) It is a structural analogue of the carnitine precursor, gamma-butyrobetaine, a substance found in every cell of the human body. Trimethylhydrazinium propionate under conditions of ischemia restores the balance of oxygen delivery and consumption processes in cells, prevents disruption of adenosine triphosphate (ATP) transport; at the same time activates glycolysis, which proceeds without additional oxygen consumption.

Ethylmethylhydroxypyridine succinate, by blocking the process of lipid peroxidation, reduces the number of free radicals, improves the structure and function of cell membranes, neurotransmitter transport and signal transmission in synapses.

The use of a complex of trimethylhydrazinium propionate and ethylmethylhydroxypyridine succinate leads to a synergistic pharmacodynamic interaction of the two components by type conformationally selective agonism to receptors, which increases the neuroprotective activity of the drug. Under conditions of hypoxia, BRAINMAX® leads to activation of energy production in mitochondria, and under 3 conditions of reduced blood supply, it helps preserve the structure and vital activity of cells, in particular neurons and cardiomyocytes. 

• As part of complex therapy of cerebral circulatory insufficiency
• Mild cognitive impairment, accompanied by such manifestations as memory impairment, absent-mindedness, decreased ability to concentrate and learn, difficulties assimilating new information
• Reduced working capacity.
• Mental and physical overloads (including athletes, see "Special instructions")
• Asthenic conditions, including after suffering from a new coronavirus infection, accompanied by such manifestations as increased fatigue, sleep disorders, headaches, dizziness, emotional lability, cognitive impairment

The drug is low toxic and does not cause severe adverse reactions. Symptoms: decreased blood pressure, accompanied by headache, tachycardia, dizziness, and general weakness. Drowsiness, insomnia.

Meldonium From the blood and lymphatic system
Frequency unknown: eosinophilia. From the immune system
Rarely - allergic reactions (redness of the skin, skin rash, urticaria, itching, swelling, angioedema).
From the side of the heart
Very rare: tachycardia.
From the vascular side
Rarely: decrease or increase in blood pressure.
From the gastrointestinal tract
Often: dyspeptic symptoms.
From the nervous system
Often: headaches;
Frequency unknown: arousal.
General violations
Frequency unknown: general weakness.
Ethylmethylhydroxypyridine succinate Disorders of the immune system:
Very rare: angioedema, urticaria.
Disorders of the gastrointestinal tract:
Very rare: dry mouth, nausea, pain, burning and discomfort in the epigastric region, heartburn, flatulence, diarrhea.
Disorders of the nervous system:
Very rare: headache.
Disorders of the skin and subcutaneous tissues:
Very rarely - rash, itching, hyperemia.
Mental disorders:
Very rarely - drowsiness.

• hypersensitivity to the components of the drug;
• acute liver failure; - acute renal failure;
• increased intracranial pressure (with impaired venous outflow and intracranial tumors);
• pregnancy;
• lactation period;
• children under 18 years of age.

Meldonium Enhances the effect of coronarodilating agents of some antihypertensive agents of cardiac glycosides. It can be combined with prolonged forms of nitrates with other antianginal agents, anticoagulants, antiplatelet agents, antiarrhythmic agents, diuretics, bronchodilators.
Due to the possible development of tachycardia and arterial hypotension, caution should be exercised when combined with nitroglycerin (for sublingual use) and antihypertensive agents (especially alpha blockers and short-acting forms of nifedipine).
Simultaneous use of the drug with other drugs containing meldonium is not allowed, as the risk of adverse reactions may increase.
Ethylmethylhydroxypyridine succinate Ethylmethylhydroxypyridine succinate is combined with all drugs used to treat somatic diseases. Enhances the effect of benzodiazepine drugs, antidepressants, anxiolytics, antiepileptic drugs (carbamazepine) and antiparkinsonian drugs (levodopa), nitrates. Reduces the toxic effect of ethanol.

Registration certificate holder
JSC Biochemist, Russian Federation
15A Vasenko St., Saransk, Republic of Mordovia, 430030
Manufacturer
JSC Biochemist, Russian Federation
Address: 15A Vasenko St., Saransk, 430030, Republic of Mordovia
Phone number: +7 (8342) 38 03 68
Email: biohimic@promomed.pro
Internet address: promomed.ru
An organization that accepts consumer claims
JSC Biochemist, Russian Federation
Address: 15A Vasenko str., Saransk, 430030, Republic of Mordovia
Phone number: 8 800 222 95 63; 8 800 777 86 04 ( around the clock)
Email: hot_line@promomed.pro

At a temperature not exceeding 25 ° C in a secondary package. Keep out of reach of children.

3 years. Do not use after the expiration date.

They are available without a prescription.